What if I Am Taking Other Medications?
That's a really good question, especially since so many of us take medications for different conditions. It is important to know that Rozerem may be safe to use with some commonly prescribed medications. It is important to know which drugs should not be used with Rozerem and which should be used with caution.
One such drug that Rozerem should not be used with is LUVOX® (fluvoxamine), which is indicated in the treatment of obsessive-compulsive disorder. LUVOX® (fluvoxamine) has been shown to increase the Rozerem exposure level. Other less strong drugs in this class, known as CYP1A2 inhibitors, have not been studied adequately. Because of this, your healthcare provider should use caution in prescribing Rozerem with these other drugs.
Other drug combinations that should be used with caution include when Rozerem is co-administered along with strong CYP enzyme inducers (rifampin), strong CYP3A4 inhibitors (ketoconazole), and strong CYP2C9 inhibitors (fluconazole). The strong CYP enzyme inducer rifampin is an antibiotic that may be used to treat certain bacterial infections. Rifampin has been shown to decrease the Rozerem exposure level. The strong CYP3A4 inhibitor ketoconazole is an antifungal medication that is indicated for the treatment of certain fungal infections. Ketoconazole has been shown to increase the Rozerem exposure level. The strong CYP2C9 inhibitor fluconazole is an antifungal medication that is indicated for the treatment of certain fungal infections. Fluconazole has been shown to increase the Rozerem exposure level.
As a rule of thumb, you should always tell your healthcare provider about any medications—either those available over-the-counter or by prescription–that you are taking as well as any vitamins or herbal supplements. Be sure to do so at your next appointment.
